What Do You Need to Prepare Before Your First Semaglutide Dose?
If you’ve been prescribed Semaglutide for type 2 diabetes or weight management, you might feel unsure: What should I do to get ready for my first dose, and how can I make the process smooth? Preparing ahead helps reduce anxiety, avoid mistakes, and set you up for successful treatment—here’s your step-by-step guide.
First, confirm your medication details and storage. Whether you’re getting injectable (Ozempic, Wegovy) or oral (Rybelsus) Semaglutide, double-check the brand, dosage, and expiration date with your pharmacist. Injectable pens need proper storage: Unused pens go in the fridge (36–46°F/2–8°C), but once opened, most can stay at room temperature (below 77°F/25°C) for up to 56 days—never freeze them. For oral tablets, store them in their original blister pack (away from moisture and heat) until you’re ready to take them. Keep a note of storage rules to avoid ruining the medication.
Second, gather supplies (for injectable Semaglutide). If you’re using an injection pen, you won’t need extra needles (most pens have pre-attached, disposable needles), but keep alcohol swabs on hand to clean the injection site (abdomen, thigh, or upper arm). Have a small trash bag nearby to dispose of used pens safely (don’t throw them in regular trash—check local rules for medical waste). For oral Semaglutide, you’ll just need a small sip of water (no more than 4 ounces) to take the tablet—avoid coffee, juice, or food for 30 minutes after.
Third, review how to use your Semaglutide correctly. For injectable pens, watch the manufacturer’s tutorial video (most brands have them online) or ask your pharmacist to demonstrate. Key steps: Clean the site with an alcohol swab, twist or click the pen to set the dose, inject at a 90-degree angle (no need to pinch skin unless you’re very thin), and hold the pen for 5 seconds to ensure the full dose is delivered. For oral tablets, take it first thing in the morning on an empty stomach—swallow whole (don’t crush or split) with a tiny amount of water.
Fourth, plan for potential side effects. The first dose may cause mild nausea, fatigue, or dizziness, so schedule it on a day when you don’t have heavy commitments (like a weekend). Keep bland snacks (crackers, bananas) and water nearby to ease nausea. Avoid driving or operating heavy machinery if you feel tired after your first dose—wait to see how your body reacts.
Finally, share your plan with a healthcare provider. Before your first dose, confirm with your doctor that you understand the dosage schedule (e.g., starting with 0.25 mg weekly for injectable) and who to call if you have questions (your doctor or pharmacist). Jot down their contact info in case you need help after hours.
Preparing for your first Semaglutide dose doesn’t have to be stressful—with these steps, you’ll feel confident and ready to start your treatment journey. Remember, it’s normal to have questions, so don’t hesitate to reach out for support.
